COX2 and PGE2 9K activities were decreased by RU534 in the CL at Day 11, whereas in the uteri COX2 increased and PGE2 9 K decreased at Days 6 and 11 natural viagra for men In still another aspect, the present disclosure relates to a composition comprising Z endoxifen or a salt or polymorph thereof prepared by any of the processes described herein for the treatment and prevention of a hormone dependent breast disorder, a hormone dependent reproductive tract disorder, or both, wherein the hormone dependent breast disorder is breast cancer and wherein the breast cancer is a pre cancer, an early stage cancer, a non metastatic cancer, a pre metastatic cancer, a locally advanced cancer, or a metastatic cancer